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Published -
- January 18, 2020
- 4:00 pm
Individuals with sickle cell disease are homozygotes of the sickle gene. This is a genetic mutation that developed on the beta chain of red blood cell hemoglobin, that is protective of malaria, endemic in equatorial Africa, where the mutation is currently known to have originated from.
It follows Mendelian inheritance. Sickling will pain, anemia, chronic tiredness, and kidney damage, among others.
Sickle cell trait refers to heterozygosity. In trait, the RBC’s don’t typically sickle in the body, but they will in places that are particularly hypertonic and hypoxic. The foremost example of that type of environment, is the kidney medulla. Hypertonicity and hypoxia are favored in this tissue because of its function in water reabsorption in the Loop of Henle. The descending loop into the inner medulla is permeable to water only. As more water flows out into the medulla, it becomes dilute. In the ascending limb of the Loop of Henle, ions can be pumped out of the filtrate and in to the medulla, maintaining hypertonicity of the tissue, allowing more water to be reabsorbed.
In the vasa recta, the RBC’s will sickle into the medulla, causing vaso-occlusion. Meaning the mechanisms of maintaining medulla hypertonicity will be compromised, turning hypoxia to become anoxia (pO2 = 0). This damage will force all filtrate to become urine, so water loss will ensue.
In extreme exercise, this will cause hemoconcentration, hypoxemia, worsening lactic acidosis, and increased sickling.
What are the potential long-term consequences of ignoring signs of pain or discomfort during exercise, and how can athletes avoid these risks?
An Athlete Squatted 500 Reps In 20 Minutes – This Is What Happened To His Kidneys
In the world of athletics, there is a constant pursuit of achieving greatness and pushing oneself to the limit. Athletes engage in various exercises and workouts to improve their performance, and they often go to extreme lengths to achieve their goals. However, sometimes this can result in serious consequences, as in the case of an athlete who recently squatted 500 reps in just 20 minutes.
The athlete in question was a professional weightlifter who frequently engaged in intense workout routines. In this particular exercise, he set out to squat 500 reps in just 20 minutes. The athlete was confident in his ability to complete the workout and was determined to achieve this goal. However, what happened to his kidneys afterwards was unexpected.
Following the completion of the exercise, the athlete began to experience intense pain in his lower back and abdomen. Initially, he brushed it off as just muscle soreness and assumed that it would pass with time. But as the pain continued to worsen, the athlete became concerned and sought medical attention.
Tests revealed that the athlete was suffering from rhabdomyolysis, a condition where muscle tissue breaks down and releases a protein called myoglobin into the bloodstream. This protein can cause damage to the kidneys, and in severe cases, it can lead to kidney failure. In this particular case, the athlete’s kidneys had suffered severe damage due to the extreme workout routine.
While rhabdomyolysis is a rare condition, it is not uncommon for athletes to push themselves to the limit and engage in intense exercise routines that can cause muscle damage. It is important for athletes to be aware of the risks associated with such workouts and take the necessary precautions to avoid injury.
It is also important for athletes to listen to their bodies and pay attention to any signs of pain or discomfort. Ignoring these signs can lead to serious health complications and can have long-lasting consequences.
In conclusion, while it is important for athletes to push themselves and strive for greatness, they must also be aware of the risks associated with intense workout routines. The athlete who completed 500 reps in 20 minutes is a reminder of the potential dangers of pushing oneself too far. It is crucial for athletes to prioritize their health and take precautions to prevent injury, and to seek medical attention if necessary. Spending a day in the hospital recovering from an exercise-related injury is not worth the short-term satisfaction of pushing beyond one’s limits.
